The pathophysiological relationship between exposure to particulate matter and cardiovascular diseases as infarction and strokes entails oxidative stress, with markers such as oxidized lipids, in addition to inducing a prothrombotic state: exposure induces the production of fibrinogen, von Willebrand factor, and other coagulation factors, and activates antifibrinolytic pathways, increasing plasma viscosity and activating platelets. Here, VWF is linked to cardiovascular disorder.