SHANK2 and breast cancer: Out of 6 cell lines analyzed, high metastatic potential breast cancer cells (BT549 and MDA-MB-231) exhibited high SHANK2 di-methylation levels, whereas normal mammary epithelial cell (MCF10A), low metastatic potential breast cancer cell (MCF7, BT474 and T47D) showed relatively low SHANK2 di-methylation level (Figure 3F and G).