CGAS and cancer: Accumulating data have been reported that acute genomic stressors, including radiation, cisplatin, and intrinsic DNA damage generate cytosolic dsDNA and micronuclei to activate cGAS–STING in cancer cells (Ahn et al., 2014; Harding et al., 2017; Mackenzie et al., 2017; Dou et al., 2017).