To investigate whether SOCS5 regulates the tumorigenesis of NSCLC by participating in lncRNA HCG11/miR‐522‐3p axis, HCG11 siRNA or miR‐522‐3p mimics was transfected into NCI‐H23 cells containing SOCS5 vector. The gene discussed is SOCS5; the disease is non-small cell lung carcinoma.