They eliminate invading pathogens and cancer cells by various mechanisms, including inflammation, reactive oxygen species release, complement activation, receptor‐mediated killing, phagocytosis, and autophagy.[40] Inflammatory mediators—such as histamine, defensins, lysozyme, chemokines, and cytokines like interferon (IFN) and tumor necrosis factor (TNF)‐α—are often secreted during acute inflammation to clear the initial cause of cell injury and tissue damage; classic symptoms accompanying inflammation include heat, pain, redness, swelling, and loss of function. The gene discussed is TNF; the disease is cancer.