The other groups, however, have lowerlevels of TS% and s-ferritin in studies without screening criteria leading us toconclude that the applied conditions for eligibility for HFE genotyping in the SIOS mainly discriminate donors with HFE mutations less strongly linked to hemochromatosis.Further support for this conclusion can be found when comparing the composition ofthe genotyped group in the SIOS compared with what has been reported in the generalpopulation (Fig. 2). The gene discussed is HFE; the disease is hemochromatosis.