TRG1 corresponds to an absence of tumor cells, replaced entirely by abundant fibrosis; TRG2 to rare scattered residual tumor cells and abundant fibrosis; TRG3 to a large amount of residual tumor cells with predominant fibrosis; TRG4 to tumor cells predominating over fibrosis; and TRG5 to almost exclusively tumor cells without fibrosis. The gene discussed is LDHB; the disease is neoplasm.