These include serine/threonine kinases such as AKT/PKB (protein kinase B), tyrosine kinases of the TEC (tyrosine kinase expressed in hepatocellular carcinoma) family particularly relevant for immune cells, modulators of small GTPase activities (various GEFs and GAPs (GTPase activating protein)) and scaffolding proteins (such as GAB (Grb2 (growth factor receptor bound protein 2)-associated binder) proteins). Here, GRB2 is linked to hepatocellular carcinoma.