In the top-list of genes with increased expression are several proteins that have shown to play a role in activation of the immune response in MS like EPSTI1 and IFI6.17,18 In the top-list of genes with reduced expression RPS6KA3 is of interest, as this gene has been shown to be downregulated in blood from MS patients in remission.19 This evidence concerns the gene RPS6KA3 and myeloid sarcoma.