Expression of adipose tissue thermogenic genes (Pgc1α, Cidea, Prdm16 and Dio2) and skeletal muscle thermogenic genes (Pparα, Pparδ, Cpt1α, Pgc1α and Pgc1β) were significantly increased in CKD mice (Fig. 2). The gene discussed is PPARGC1B; the disease is chronic kidney disease.