Vitamin D repletion attenuated increased expression of both adipose tissue (Pgc1α, Cidrea, Prdm16 and Dio2) and skeletal muscle (Pparα, Pparδ, Cpt1α, Pgc1α and Pgc1β) thermogenic genes in CKD mice (Fig. 2). Here, DIO2 is linked to chronic kidney disease.