The novel regulatory relationships BRD4 → CCNB1 and CCNB1 → MYC (Fig. 3) were examined in an independent study27 in which JQ1 was used to inhibit BRD4 in the GTML2 cell line, a mouse brain tumor cell line that overexpresses human MYCN. The gene discussed is BRD4; the disease is brain neoplasm.