FXII autoactivation can be influenced by multi-factors, such as FXII38 and C1INH levels39, ionic milieu18,40, or the negative charge density of FXII activators41, etc. Indeed, our data also showed that plasma from different human individuals had vastly different amidolytic activity in response to penicillin (Fig. 5B and Supplementary file 2), of which high responders might be the potential anaphylaxis sufferer (e.g., no. 6 in Fig. 5B and no. 5 in Supplementary file 2). The gene discussed is SERPING1; the disease is anaphylaxis.