The p53-DREAM pathway genes CDKN3, DEPDC1, BIRC5, BRIP1, and RFC4 were all strongly associated and down-regulated in tumours with intratumoural CD68+ macrophage infiltration.41 None of these genes was affected by BRAF status, indicating that this pathway is regulated by macrophages. This evidence concerns the gene BIRC5 and neoplasm.