We used CRISPR-Cas9 to delete ZNF148 in H838, A549, and H1299 (TP53 null) human lung cancer cells (Fig. 5A and Supplementary Fig. S3), and confirmed that p53-induction by etoposide was intact (Fig. 5B and Supplementary Fig. S3). This evidence concerns the gene TP53 and lung carcinoma.