There was no evidence of genetic interaction between ZNF148 and TP53 in CRISPR and siRNA screens of hundreds of human cancer cell lines, performed under conditions that revealed strong dependencies between TP53 and known repressors of p53 activity including MDM2, MDM4, and PPM1D. Moreover, the was no evidence of genetic interaction between ZNF148 and TP53 under DNA damaging conditions in human lung cancer cells or mice. This evidence concerns the gene MDM4 and cancer.