Since the integrated transcriptomic and promoter occupancy analysis suggested pleiotropic and indirect mechanisms of p53 and ARF activation in Zfp148gt/gt MEFs, we decided to explore the genetic interaction between ZNF148 (the human orthologue of Zfp148) and TP53 in CRISPR and siRNA data from human cancer cell lines. The gene discussed is ZNF148; the disease is cancer.