Although VEGF inhibitor has been applied in various cancers due to its ability to reduce hypoxia-induced excessive angiogenesis,205,206 a great number of hypertension cases in cancer patients and increased arterial vascular events have been reported.207 Carvedilol may benefit the reversal of VEGF-induced hypertension due to its vasodilatory effect.207. This evidence concerns the gene VEGFA and hypertensive disorder.