PDCD1 and cancer: Previous studies have shown that platelet activation results in an immunosuppressive TME and spares cancer cells from immune surveillance, leading to their growth and migration.139,169 Considering that aspirin is one of the most commonly used antiplatelet drugs, Riesenberg et al.169 revealed its antitumor activity on the immune microenvironment and found its potential use in combination with PD-1 blockade.