in the gynecologic tract are correlated with the occurrence of endometrial cancer for unknown reasons.245 Microbiota (Bifidobacterium) accumulated in colon adenocarcinoma promotes immunotherapy by activating STING signaling.246 Nejman et al.247 demonstrated that bacteria are present in cancer or immune cells, further confirming the presence of microbiomes in TME, although its role remains unknown. This evidence concerns the gene STING1 and cancer.