Moreover, the mechanical stiffness of ECM is reported to accelerate glioblastoma cell progression.36 Cancer-produced ECM promotes the colonization of breast cancer lung metastasis through platelet recruitment via heat shock protein 47/type I collagen axis.133 Lu et al.134 and Leight et al.,33 provided informative discussions on the role of ECM in the modulation of cancer biology and treatment. This evidence concerns the gene SERPINH1 and cancer.