Hypoxia-induced VEGF expression is a typical product of the reshaping of immune microenvironment96 Horikawa et al.136,137 Sonveaux et al.101 demonstrated a phenomenon called “glycolytic switch” and “metabolic symbiosis”, and stated that oxidative cancer cells prefer utilizing lactate rather than glucose, in which MCT1 mediates a lactate exchange in tumors.138 Hypoxic cells consume glucose and produce lactate, which can diffuse based on the concentration gradient, whereas oxidative cancer cells uptake lactate via MCT1. This evidence concerns the gene VEGFA and cancer.