CD8A and lung cancer: This phenomenon suppresses the survival of lung cancer cells and indicates statin’s repurposing application in targeting the immune microenvironment.240 In a B16 melanoma lung metastatic model, statin lowers PD-1 expression in CD8+ T cells and effectively restores antitumor activity.96 These findings support the adjuvant role of statins combined with chemotherapy, radiotherapy, and targeted therapy (Table 1).