For example, treatment of BLZ945 (colony-stimulating factor-1 receptor inhibitor) inhibits macrophages, induces tumors regression, and prolongs survival in glioblastoma-bearing mice, whereas over 50% glioblastomas recur.157,158 Quail et al.158 demonstrated that the high relapse rate is due to acquired resistance and thus proposed the requirement of combination therapy. This evidence concerns the gene CSF1R and glioblastoma.