PTGS2 and malignant colon neoplasm: Regular use of aspirin is associated with lower risk of BRAF-wild-type colon cancer.163 It also exhibits antitumor activity in cancers including ovarian, gastric, and pancreatic through diverse mechanisms.164–166 Aspirin has an inhibitory effect on the cyclooxygenase (COX)-1 and COX-2 pathway to inhibit cancer proliferation, metastasis, and angiogenesis.