NPM1 and acute myeloid leukemia: The comparison of ARs in 19 FLT3-ITDmut/NPM1 double-mutant AML, showed that FLT3-ITDmut allelic burden was heterogeneous and significantly lower than that of NPM1 (median FLT3-ITDmut AR: 0.36 vs NPM1 AR: 0.75, p = 0.001, Fig. 1a), with no correlations between the mutation loads of the two genes in individual patients (Spearman r = 0.07, p = 0.74).