PIK3CA and colonic neoplasm: IGF-1R inhibition has been shown to inhibit PI3K/AKT and Ras/ERK signaling pathways.26 However, previous studies showed that ERK phosphorylation is barely suppressed in several colon tumor cell lines treated with IGF-1R inhibitor, OSI-906.27 Thus, it is interesting to examine the effect of BMS-754807 on ERK phosphorylation.