IGF1R and malignant colon neoplasm: Previously, we found that prolonged treatment of colon cancer cells with an IGF-1R inhibitor, OSI-906, induces p70S6K1 activation.10 The induction of p70S6K1 activation in colon cancer cells is associated with resistance of IGF-1R inhibition since knockdown of p70S6K1 or inhibition of p70S6K1 activity enhances the cell sensitivity to IGF-1R inhibition.