RPS6KB1 and colonic neoplasm: BMS-754807 is a potent IGF-1R inhibitor, which has been reported to have a limited off-target effect since the transcriptional profile is similar between wild-type MEF cells treated with BMS-754807 and IGF-1R null MEF cells.20,21 We found that colon tumor cells treated with an IGF-1R inhibitor, BMS-754807 or GSK1838705A, induced phosphorylation of p70S6K1 as OSI-906 does.