However, colon tumor cells treated with OSI-906 suppresses AKT activation but induces p70S6K1 phosphorylation.10 This finding raises the question of whether the activation of p70S6K1 by OSI-906 is through IGF-1R inhibition or it is a non-specific effect of OSI-906. The gene discussed is AKT1; the disease is colonic neoplasm.