Because indole-3-lactate can act as a ligand for AhR, we speculate that L. crispatus may regulate the IL-22-AhR response in the vagina, reducing the risk of vaginal candidiasis in the same way IAld does, and potentially activating the AhR response in newborns to prevent early-life candidiasis. This evidence concerns the gene IL22 and Candidiasis, Invasive.