Interestingly, motif analysis of enhancer H3K27ac by ChIP-Seq implicated the Ets family TF FLI1 as an additional candidate for a regulator of cellular enhancers in PEL, reminiscent of the recently reported cooperation of FLI1 with IRF4 on SEs in multiple myeloma (31). Here, IRF4 is linked to plasma cell myeloma.