In these other settings, IRF4 binds to enhancers, including tightly clustered enhancers referred to as “super-enhancers” (SEs), to drive overexpression of MYC or, in ATLL, the essential IRF4 cotranscription factor BATF3 (basic leucine zipper ATF-like TF 3 [27, 31, –, 34]). This evidence concerns the gene IRF4 and adult T-cell leukemia/lymphoma.