Thus, in the neoplastic cell lines, the differential associations of IRF4 occupancy seen in the ABC to plasmablast transition were recapitulated, and IRF4 association with binding sites enriched for CTCF motifs was found as a significantly more prominent feature in the PC myeloma than ABC-DLBCL cell lines tested. The gene discussed is CTCF; the disease is diffuse large B-cell lymphoma.