CD8A and neoplasm: B lymphocytes, or B cells, can have immunosuppressive activity in several tumor types.47–50 B cells can associate with CD8+ T cells in both murine PDAC models and pancreatic intraepithelial neoplasias (PanIN) of patients.48 50 Several studies have uncovered B-cell phenotypes in PDAC, and targeting these cells improves immune responses in PDAC.48–50 Emerging reports highlight a role for B-cell-derived IL-35, as well as B-cell control of macrophage polarization to a tumor-promoting phenotype.