Indeed this is where the majority of Tregs in tumor-bearing mice are found.53 This research also revealed CTLA4/CD80 interactions between Tregs and dendritic cells (DCs) as essential molecular mediators of CD4 T-cell exclusion, but the specifics of how CD4 T cells are actually excluded as a result of these interactions are only now becoming clear. The gene discussed is CD4; the disease is neoplasm.