Interestingly, immunosuppressive Tregs and B cells with regulatory properties can localize to stromal areas of PDAC, rather than within foci of adenocarcinoma.9 47–50 These Tregs are most often characterized as CD4-positive, with high expression of the IL-2 receptor CD25 and the transcription factor Forkhead Box P3 (FOXP3). The gene discussed is FOXP3; the disease is adenocarcinoma.