This diversion, in turn, activates protein kinase C (PKC) and upregulates the phosphorylation of insulin receptor substrate-1 (IRS-1) [52], lowering its activation and subseqently inhibiting the PI3K/AKT signaling pathway, which is a key pathway regulating the cell cycle and is thus directly related to cellular quiescence, proliferation, and cancer. This evidence concerns the gene IRS1 and cancer.