CD46 and age-related macular degeneration: For the CD46 lead variant, we identified 27 significant trait associations (FDR < 5%), including four with particularly strong evidence (P < 5.0 × 10− 8; white blood cell, neutrophil, monocyte count and plateletcrit); the early AMD risk increasing allele (G, frequency = 79%) was associated consistently with increased blood cell counts.