Among the 10 identified loci (any tier), two were reported previously for early AMD (near CFH, ARMS2/HTRA1) and eight were identified here for the first time for early AMD with statistical significance (near CD46, C2, C3, CETP, TNFRSF10A, VEGFA, APOE/TOMM40/PVRL2 and TYR). This evidence concerns the gene CD46 and age-related macular degeneration.