The locus around CD46 had been reported as suggestive for early AMD by the previous largest GWAS for early AMD [12] (4089 early AMD cases, 20,453 controls), but not with statistical significance, and had not been identified with statistical significance by the previous largest GWAS for advanced AMD [9] (16,144 advanced AMD cases, 17,832 controls). The gene discussed is CD46; the disease is age-related macular degeneration.