This novel locus around rs4844620 (near CD46) is independent of known (advanced) AMD loci: rs4844620 is (i) ~ 500 K base positions distant from the recently reported AMD locus near C4BPA/CD55 [11] and uncorrelated to the reported C4BPA/CD55 lead variant rs11120691 (r2 < 0.01) and (ii) > 10 million base positions distant from the CFH locus and uncorrelated to any of the eight reported CFH locus variants, r2 < 0.01). Here, C4BPA is linked to age-related macular degeneration.