TYR and age-related macular degeneration: For the TYR lead variant (rs621313, G allele associated with increased early AMD risk, frequency = 48%), we identified 20 significant trait associations including Melanoma (FDR < 5%, G allele associated with increased Melanoma risk) and two with particularly strong evidence for skin color and ease of skin tanning (P < 5.0 × 10− 8, G allele associated with brighter skin color and increased ease of skin tanning).