C3 and age-related macular degeneration: Most of the eight loci overlap with known loci for advanced AMD [9] (CFH, ARMS2/HTRA1, C2, C3, CETP, VEGFA, TNFRSF10A), except one which has not been identified in early or advanced AMD GWAS before (P = 4.7 × 10− 8, lead variant rs4844620, near CD46, Figure S1).