Metastasis of CRC is a multistep process requiring the accumulation of genetic and/or epigenetic alterations and abnormal expression of genes involved in signal transduction pathways, including oncogenic mutation of KRAS and activation of the ERK/MAPK pathway, Wnt/β-Catenin signalling and TGFβ signalling [23]. Here, TGFB1 is linked to colorectal carcinoma.