PERP and pancreatic neoplasm: To understand the role of PERP in METTL14-induced pancreatic cancer growth, we knocked down PERP in pancreatic cancer cells depleted of METTL14. We found that PERP depletion notably increased the viability and colony formation of PANC-1 cells, but also abrogated the decrease of it under knockdown of METTL14 (Fig. 6a, b).