WIF1 and neoplasm: Although it was confirmed that ALKBH5 functions as a tumor-suppressor gene, involved in sensitizing pancreatic cancer cells to chemotherapy via direct impact on Wnt inhibitory factor 1, the m6A eraser was also reported to prevent pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent Manner [35, 36].