TTN and non-small cell lung carcinoma: Although DNA damage repair (DDR) genes, negatively predictive genes (STK11 and KEAP1), and TMB-associated genes such as MUC16, POLE, POLD1, and TTN have been included in the NGS panels for TMB evaluation [10–14], with the burgeoning developments in immunotherapy, there is a need for more specific panels that focus on TMB estimation for NSCLC.