On one hand, the increased proportion of OX40L+ cells in lymph node of DNCB induced AD mice was suppressed by SBT oil administration which confirmed the effect of SBT oil on activation of CD4+ T cells, On the other hand, SBT oil conduced to the normal function of LCs through renovating the keratinocyte and suppressing TSLP release. The gene discussed is TSLP; the disease is Alzheimer disease.