In this study, we employed DNCB-induced AD model using BALB/c mice which has been proposed as an appropriate representative of human AD because of similar symptoms including skin erosion, hemorrhage, epidermal hyperplasia, mast cell infiltration and increased IgE level in serum etc. SBT oil, as a traditional herbal extracts, have been proved diversified pharmacological actions such as anti-inflammatory, relieve the pressure, protecting vascular endothelial cell and immunomodulatory effects [25, 26]. The gene discussed is IGHE; the disease is Alzheimer disease.