SPP1 and urolithiasis: For the first time, we present a genetic association study investigating the role of common genetic variants in SPP1 gene using a sample set of Pakistani patients manifesting clinically significant urolithiasis where we demonstrate significant association of three SPP1 promoter polymorphisms (rs2853744:G > T, rs11730582:T > C and rs11439060:delG>G) with urolithiasis.