Among the up-regulated TME transcripts of Figure 3J, the most relevant are the breast cancer 1 gene Brca1, and Sp110. Sp110 is a member of the SP100/SP140 family of nuclear body proteins that encodes a leukocyte-specific nuclear body component regulating genes involved in the inflammatory response and miRNA expression in macrophages. Here, SP140 is linked to breast carcinoma.