BRCA1 and keratoconus: We performed the analysis for Brca1 Expression, DEM targeting Brca1, and DEG and DEP of other genes and proteins targeted by the miRNAs that target Brca1. As a control with which to compare these distributions, we used the distributions of all the DEM, DEG, and DEP associated with molecules not targeted by miRNA that target Brca1. The analysis was performed for differentially expressed molecules in ET vs. EC in Figure 5B, IT vs. IC in Figure 5C, and KT vs. KC in Figure 5D. We observed that miRNAs targeting Brca1 were generally down-regulated in tumor endothelial cells.