The network analysis of miRNAs, target genes and transcription factors highlighted interesting interactions among them and relevant circuitries containing cancer key genes, such as TP53, BRCA1, Myc, ERS1, PI3K and pathways (e.g., KEGG breast cancer, apoptosis, p53, PI3K-Akt, MAPK, cell cycle). The gene discussed is TP53; the disease is breast cancer.