PMEPA1 and Familial prostate cancer: Subsequently, additional three isoforms of PMEPA1 gene were reported with ORF coding for 237 amino acids (PMEPA1-c) in colon and breast cancer [7,13], 259 amino acids (PMEPA1-d) in lung cancer [14] and 344 amino acids (PMEPA1-e) in prostate cancer [1].