TARDBP and Alzheimer disease: In this biosensor, AuNPs combined with PAMAM were used as scaffolds for the immobilization of antibodies to dual SPCEs, while HRP functionalized with antibodies was used for the amperometric detection of AD biomarkers using H2O2 / hydroquinone system as reporter, providing a LOD of 50 fM for tau-441 and 0.287 pM for TDP-43.