MPO and Alzheimer disease: We uncovered positive correlations between MPO levels and PAR concentrations in the putamen of both AD patients with the homozygous GG mutation in TSPO and PDD patients with the heterozygous AG mutation in TSPO. PAR synthesis was induced by 100 μM H2O2 in the lymphoblastoid Raji cells [36] and is dependent on the number of damaged DNA sites [61].