As shown in Figure 4e, Spearman analyses revealed negative correlations between TSPO density and TREM2 concentration in the putamen of PDD brains (rs = −0.88, p = 0.004), as well as TSPO density and MPO concentration in the putamen of the PD patients carrying BIN1 with heterozygous AG (rs = −0.900, p = 0.037). Here, BIN1 is linked to Parkinson disease.