Importantly, DAA-resistant cancer cells retained their susceptibility to the cytotoxic chemotherapy drugs cisplatin (alkylating agent) and docetaxel (antimitotic), as well as the estrogen receptor antagonist tamoxifen that also induces apoptosis in estrogen receptor-negative breast cancer cells via inhibition of cancerous inhibitor of protein phosphatase 2A [19]. The gene discussed is ESR1; the disease is cancer.