PTGS2 and neurodegenerative disease: QU has been found to decrease the inflammatory state induced by cholesterol oxidation products, a risk factor in neurodegenerative diseases, to lower the expression of pro-inflammatory cytokines, such as interleukin-6, tumor necrosis factor-α, interleukin-1b, and to inhibit the expression/activity of the cyclooxygenase-2 (COX-2) by suppressing the COX-2 mRNA expression [2].