TP53 and non-small cell lung carcinoma: Another of the aptamers selected by Zhao et al. against A549 lung cancer cells, S6, was conjugated by Wang and colleagues [72] with polyamidoamine (PAMAM) through difunctional PEG to create a dendritic structure able to encapsulate and selectively deliver to NSCLC cells miR-34a (Figure 5b), whose role in hindering the proliferation and metastasis of NSCLC through the regulation of oncogenes or tumor suppressors, including p53 and BCL2, had been already highlighted [73].