SERPINE1 and neoplasm: The main components of the uPAS system are the urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), plasminogen activator inhibitor-2, tissue-type plasminogen activator, and the uPA receptor, all of which play a central role in inflammation, matrix remodelling during wound healing, tumour invasion, angiogenesis, and metastasis.