Other links between the endosomal recycling pathway and AD include the statistically significant association of a Rab11 variant (rs117150201; T to G substitution in the 3′ UTR) with increased risk of late-onset AD [42] and the finding that mutations in the SORL1 gene, which encodes the multifunctional intracellular sorting protein SORLA, have been associated with both early- and late-onset AD [46]. The gene discussed is SORL1; the disease is Alzheimer disease.