MSH2 and Lynch syndrome: Besides this syndrome, there are other genes associated with an increased risk of GC: STK11 (Peutz–Jeghers syndrome), SMAD4/BMPR1A (juvenile polyposis), MLH1/MSH2/MSH6/PMS2 (Lynch syndrome), APC/MUTYH (familial adenomatous polyposis), BRCA2/BRCA1/PALB2/ATM (hereditary breast-ovarian cancer syndrome, HBOC) and TP53 (Li-Fraumeni syndrome) [13,14,15].