The following factors are used to calculate the risk score: (1) Abdominal imaging, such as MRI, CT, and EUS; (2) carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels; (3) analysis of KRAS and GNAS mutations; and (4) cyst fluid cytology. The gene discussed is KRAS; the disease is cyst.