Interestingly, DNMT3A mutations are found at low rates below 5% in primary MPN (PV and ET) but appear to be more frequent in advanced MPN (10–15% of PMF, 15% of secondary MF, and 17% of AML arising from MPN) [115,116,117]. The gene discussed is DNMT3A; the disease is myeloproliferative neoplasm.