Genes encoding epigenetic regulators such enhancer of zeste homologue 2 (EZH2), DNA methyl transferase 3A (DNMT3A), and additional sex combs-like 1 (ASXL1) are among the most frequently mutated genes in patients with MPN [74,75,76]. The gene discussed is DNMT3A; the disease is myeloproliferative disorder.