In summary, by altering the integrity of the ECM and by inducing premature senescence, LMNA mutations could affect the stem cell lineage determination and consequently interfere with the proper differentiation of adipocytic cells in FPLD2 associated with mutations of LMNA. As MDs are a common feature of laminopathies, it is important to increase our knowledge concerning the cell mechanobiological property changes linked to LMNA mutations and their effects on cell differentiation and lineage. The gene discussed is LMNA; the disease is laminopathy.