Studies on capsaicin-independent anti-diabetes effects have recently reported that icariside E5-rich RPSE (100 and 200 mg/kg bw) reduced fasting glucose levels, insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) in high-fat-induced obesity mice [18,20]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.