GPT and metabolic dysfunction-associated steatotic liver disease: The ALT-threshold definition is more parsimonious and by not including a metabolic risk factor facilitates the conduct of further genetic correlation or causal inference studies (via Mendelian randomization) to investigate the links between these individual metabolic risk factors and NAFLD (by not conditioning a phenotype on a metabolic risk factor performing causal inference studies of the influence of a risk factor and NAFLD would become problematic potentially inducing collider bias) [54].