In the Hodgkin’s lymphoma cell lines (latency II) as well as EBV-infected lymphoblastoid cell lines (latency III), it is more complicated that EBV increases the expression of DNMT3A through an uncharacterized viral gene(s) but down-regulates the expression of DNMT1 and DNMT3B expression through LMP1 [80]. The gene discussed is DNMT3A; the disease is Hodgkins lymphoma.