EGFR and non-small cell lung carcinoma: According to the Kyoto Encyclopedia of Genes and Genomes database, EGFR and its underlying mechanisms appear dependent on the intracellular Ca2+ ([Ca2+]i) signaling pathway in NSCLC, in which EGFR activation sequentially elicits phospholipase Cγ (PLCγ) phosphorylation, inositol trisphosphate (IP3) production, Ca2+ release from the endoplasmic reticulum (ER), and protein kinase C activation.