In conjunction, these results suggested that OPG and RANKL were not directly associated with the lower level of bone neoformation observed in the hyperglycemic animals and that other metabolic pathways (Wnt/β-catenin, semaphorins, bone morphogenetic proteins, metalloproteinases) must be studied in an endeavor to elucidate the mechanism responsible for the reduction in alveolar bone neoformation associated with hyperglycemia.β Here, TNFSF11 is linked to Hyperglycemia.