PFKFB3 and idiopathic pulmonary fibrosis: Overexpression of p53 in hfLfs from IPF tissue explants reduced the expression of HK2, PKM, PFKP, PFKFB3, and HIF-1α, while naive fLfs or fLfs exposed to Ad-Ev still displayed elevated baseline levels of glycolytic enzymes (Figure 2A).