PFKFB3 and pulmonary fibrosis: Pulmonary fibrosis induced with BLM caused dysregulation in glycolysis in both p53fl/fl (Figure 8, C and D) and p53cKO (Figure 8, E and F) mice, as indicated by the increased expression of HK2, PKM, PFKP, PFKFB3, and HIF-1α protein and their mRNAs in whole lung homogenates.