In this respect, miR‐101 was found to be downregulated in human RB tissues and experimentally shown to inhibit EZH2 expression by targeting its 3′UTR, providing a mechanistic link between EZH2 overexpression and miR‐101 downregulation in human RB tumors (Lei et al., 2014). This evidence concerns the gene EZH2 and retinoblastoma.