RB1 and retinoblastoma: Adenoviral antisense‐mediated blocking of HMGA2 synthesis inhibited RB cell proliferation, and microRNA profiling in HMGA2‐knockdown RB cells indicated that miR‐106b~25 cluster may be a key downstream mediator for the oncogenic functions of HMGA2 in RB by modulating the expression of p21 and BIM (Chau et al., 2003; Venkatesan et al., 2014).