Apart from augmentation of apoptosis in UHRF1‐depleted cells in response to HDACi treatment, the study also showed that UHRF1 downmodulation derepresses expression of photoreceptor‐specific genes in RB cells by decreasing HDAC association and concomitantly increasing histone H3 acetylation at the gene promoters, demonstrating that UHRF1 plays a role in epigenetic repression of differentiation‐associated genes in RB cells (Kim et al., 2020). The gene discussed is UHRF1; the disease is retinoblastoma.