Notably, chromatin regulators Hells and Uhrf1 were identified to be expressed in murine RB tumors, but their expression was abrogated in E2f1 or E2f3‐deficient background in the same murine RB model with a concomitant rescue of the tumor development phenotype (Benavente et al., 2014). This evidence concerns the gene E2F3 and neoplasm.