However, unlike many cancer cells, UHRF1 knockdown in Y79 cells results in no gross proliferation defects except for a modest increase in apoptosis while UHRF1 depletion in Weri‐Rb1 cells has shown to induce appreciable cell cycle arrest and some increase in apoptosis via inhibition of the phosphoinositide 3‐kinase/protein kinase B signaling pathway (Kan et al., 2017; Liu, Liang, Zhou, & Liu, 2019). This evidence concerns the gene RB1 and cancer.