FIS1 and amyotrophic lateral sclerosis: Significantly, and corroborating our findings, an increase in fission, including changes in DNM1L and FIS-1, was already reported in neurons from fALS patients [157, 158], in ALS lymphoblastoid human cells [159], in ALS patient–derived fibroblasts [96], in cultured motor neurons expressing SOD1 mutant [96], and in animal models of ALS [154, 157, 160].