FIS1 and amyotrophic lateral sclerosis: Taking into consideration that changes in DNM1L and FIS-1 expression, together with mitochondrial depolarization and biogenesis modification, are related to selective mitochondrial degradation [56, 161], we hypothesized that mitophagy, the major machinery to eliminate dysfunctional mitochondria [162], could also be dysfunctional in PBMCs from ALS subjects.