While in neurologically normal postmortem human brain tissue, CD163 staining is limited to perivascular macrophages as seen in our results and observed in other studies, it has been shown to be upregulated in microglia in disease states such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, HIV encephalitis, SIV encephalitis, and traumatic brain injury [61–63]. Here, CD163 is linked to early-onset autosomal dominant Alzheimer disease.